Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator
Abstract Background Lung disease in cystic fibrosis (CF) patients is dominated by chronic inflammation with an early and inappropriate influx of neutrophils causing airway destruction.Congenic C57BL/6 CF mice develop lung inflammatory disease similar to that of patients.In contrast, lungs of congenic BALB/c CF mice remain unaffected.The basis of th